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α-Ketoglutaric acid sodium salt

CAS No. 22202-68-2

α-Ketoglutaric acid sodium salt( 2-oxoglutarate monobasic | Oxoglutaric acid | AKG )

Catalog No. M19760 CAS No. 22202-68-2

alpha-Ketoglutarate is a key molecule in the TCA cycle. It can be produced from glutamate by oxidative deamination via glutamate dehydrogenase and as a product of pyridoxal phosphate-dependent transamination reactions (mediated by branched-chain amino acid transaminases) in which glutamate is a common amino donor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    α-Ketoglutaric acid sodium salt
  • Note
    Research use only, not for human use.
  • Brief Description
    alpha-Ketoglutarate is a key molecule in the TCA cycle. It can be produced from glutamate by oxidative deamination via glutamate dehydrogenase and as a product of pyridoxal phosphate-dependent transamination reactions (mediated by branched-chain amino acid transaminases) in which glutamate is a common amino donor.
  • Description
    alpha-Ketoglutarate is a key molecule in the TCA cycle(PMID: 26759695 ). It can be produced from glutamate by oxidative deamination via glutamate dehydrogenase and as a product of pyridoxal phosphate-dependent transamination reactions (mediated by branched-chain amino acid transaminases) in which glutamate is a common amino donor.
  • In Vitro
    2-Ketoglutaric acid Sodium (Alpha-Ketoglutaric acid Sodium) has other physiological capabilities including reduction of ammonia level formed in the lung and general ammonia detoxification, protective role against lipid peroxidation and neuroprotective effect against cyanide poisoning.2-Ketoglutaric acid Sodium acts as precursor for the synthesis of amino acids and nucleotides.
  • In Vivo
    ——
  • Synonyms
    2-oxoglutarate monobasic | Oxoglutaric acid | AKG
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    22202-68-2
  • Formula Weight
    168.08
  • Molecular Formula
    C5H5NaO5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    [Na+].OC(=O)CCC(=O)C([O-])=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wu N et al. Alpha-Ketoglutarate: Physiological Functions and Applications. Biomol Ther (Seoul). 2016 Jan;24(1):1-8.
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